So let me help you wring the most from the data that’s in your hands. When we open a PDB file (a file that encodes the experimental structure of a macromolecule) in a molecular graphics program, a lot of information simply isn’t displayed!
Or you may analyze proteins routinely as part of your omics project.Įither way, information that could be crucial to forming a hypothesis or informing your experimental design, might be currently overlooked. You may isolate RNA for your experiments and rarely conduct protein structure analysis.
Whatever you research, wherever your assay targets lie on the central dogma, and wherever your native host is on the tree of life-functional proteins are involved. The central dogma of molecular biology cogently explains the one-directional flow of information from DNA into RNA, and RNA into a functional protein.Īnd what information carries more impact and functional relevance than an experimental structure?
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